My Patient Information Canvass For The Influenza Vaccine For Informed Consent.
My Patient Info Sheet for the Flu Vaccine for Informed Consent
For the Pro side delight see the https://www.cdc.gov/flu/
It is of import to review both sets of information to brand an informed decision.
1. Jefferson T, Di Pietrantonj C, Rivetti A, Bawazeer GA, Al ... (n.d.). Retrieved from https://residenciadeclinica.files.wordpress.com/2010/08/influenza-vaccines-cochrane-review-20101.pdf
Collaboration report included xl clinical trial studies of to a greater extent than than 70,000 people a perfectly matched year, it showed upward to 80% produce goodness but since that frequently doesn’t happen, it listed 50% effectiveness to every bit depression every bit 30% effectiveness amongst the flu vaccine. So merely every bit many people theoretically benefited every bit didn’t on an average year. It showed small-scale days lost from operate too NO evidence was institute to decrease hospitalization or complication rates. Another analysis seat it this way. When the vaccine matched the flu strain, 4 per centum who weren’t vaccinated got the flu. One per centum of vaccinated people got it. That’s a departure of 3 percent. When the vaccine didn’t tally the strain, 2 per centum of unvaccinated people got the flu, too 1 per centum didn’t, for a departure of 1 percent.
2. Kelley NS, Manske JM, Ballering KS, Leighton TR, Moore KA. The Compelling Need for Game-Changing Influenza Vaccines, An analysis of the flu vaccine enterprise too recommendations for the future. Center for Infectious Disease Research & Policy, Oct 2012.
It removed to a greater extent than of the “flawed” studies too institute that inward a perfectly matched year, it was 59% effective inward having the vaccine inward the ages of 18-64. It showed no produce goodness inward the elderly (over 65) or nether xviii has been seen inward other studies. Their newspaper suggests that the flu vaccine is non ideal but due to lack of fiscal incentive, to a greater extent than beneficial vaccines are non probable to last found.
3. Cowling, Fang, Kwok-Hung. Increased Non-Influenza Respiratory Virus Infections Associated amongst receipt of the Inactivated Influenza Vaccine. Clinical Infectious Diseases, Vol. 54, Issue 12, June 2012 pages 1778-1783, also inward Clin Infect Dis 2012 June 15; 54(12): 1778-83
TIV (trivalent inactivated flu vaccine) recipients had higher jeopardy of confirmed non-influenza respiratory virus infection (RR, 3.46;95% Cl, 1.19-10.1) The bulk of the non-influenzas respiratory virus detection were rhinoviruses too coxsackie/echoviruses, too the increased jeopardy amid TIV recipients was also statistically important for these viruses.
4. Minn, Michael, McCullers, J., Klugman, K. Live Attenuated Influenza Vaccine Enhance Colonization of Steptococcus Pneumonia too Staphylococcus Aureus inward Mice, mBio 5(1) doi:10.1128/mBio.01040-13
The strong too frequently lethal effects of an antecedent flu virus infection on secondary bacterial illness convey been reported. Viral replication induced epithelial too mucosal degradation, too the ensuing innate immune answer yield diminished capacity to avert secondary bacterial infections. Recent clinical too experimental information advise that flu virus infection may exert its influence outset inward the URT past times enhancing susceptibility to bacterial colonization.
5. Goldman GS Comparison of VAERS fetal-loss reports during 3 consecutive flu seasons: Was at that spot a synergistic fetal toxicity associated amongst the two- vaccine 2009-2019 season? Hum. Exp Toxicol. 2013 May;32(5): 464-75
There were 77.8 fetal loss reports per 1 1000000 important women vaccinated during the 2009/2010 2 dose flu flavor vs 6.8 fetal loss reports during the previous 1-dose flu season. An 11.4-fold increase. The ii multidose vials comprise 25 mcg of mercury per dose those years.
6. Jefferson T, Rivetti A, et al. Vaccines for preventing flu inward salubrious children. Cochrane Database Syst. Rev 2012 Aug 15; Issue 8: CD 004879
75 worldwide studies, Inc 17 randomized trials, inward children older than 2, the inactivated flu vaccine is near 36% effective. Under 2 it was equal to placebo, no evidence to demo reduced mortality, infirmary admissions, serious complications or community transmission of influenza.
7. Jefferson T, Smith S, et al. Assessment of the efficacy too effectiveness of flu vaccines inward salubrious children: systematic review. Lancet 2005 February 26; 365 (9461) : 773-80
No evidence of reduced mortality, admissions, complications, or decreased community transmission of influenza.
8. Joshi, AY, Iyer VN, et al. Effectiveness of trivalent inactivated flu vaccine inward influenza-related hospitalization inward children: a case-control study. Allergy Ashthma Proc 2012 Mar-Apr;33(2): e23-7
Study of kids half dozen months to xviii years from 1999-2007. Children who were vaccinated against flu were 3 times to a greater extent than probable to last hospitalized for flu related complications than children who did non have an flu vaccine (OR=3.67). Asthmatic children who received the flu vaccine were also to a greater extent than probable to last hospitalized than those who did non have it. The severity of asthma did non deport upon the outcome.
9. Seasonal Influenza too Vaccine Herd Effect
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083064
Study 1968-2001-Observational study showed no decreased mortality charge per unit of measurement amongst increasing vaccination from 15% to 65%
10.Thomas RE, Jefferson T, Lasserson TJ Influenza vaccination for wellness tending workers who tending for people aged threescore or older living inward long-term tending institutions. Cochrane Database Syst Rev 2013 ; Issue 7: CD 005187
No evidence to back upward that vaccinating healthcare workers inward long-term tending facilities showed effect on laboratory proven flu or complications (pneumonia, hospitalization, or expiry due to pneumonia) inward those residence over historic menses 60.
11. Doshi, P. (2013). Influenza: Marketing vaccine past times marketing disease. Bmj, 346(May16 1). doi:10.1136/bmj.f3037
Too much to listing to explicate but worth the read.
12. Doshi, P. (2005). Are United States of America of America flu expiry figures to a greater extent than PR than science? Bmj, 331(7529), 1412. doi:10.1136/bmj.331.7529.1412
(Basically, discusses this information on this page)
13. Carrat, F., Lavenu, A. et al, Repeated flu vaccination of salubrious children too adults borrow now, pay later? Epidemiol. Infect. (2006) 134, 63-70
Shows that repeated flu vaccination at a younger historic menses substantially increases the jeopardy of flu inward older age
14.Phone conversation with (protected mention now), MD, MPH, CAPT, USPHS Medical Officer Epidemiology too Prevention Branch Influenza Division, NCIRD Centers for Disease Control too Prevention
Agreed amongst all information hither too says this is the best nosotros tin do. Due to lack of evidence, they produce non officially endorse flu vaccine mandates. Also she admits that nosotros volition never convey skillful studies due to changing viral strains too vaccines that may non match.
15. Skowronski DM, De Serres G, et al. Association betwixt 2008-2009 seasonal flu vaccine too pandemic H1N1 illness during Spring-Summer 2009:four observational studies from Canada PLoS Med 2010 Apr 6; 7(4) e1000258
Recipients of the flu vaccine had significantly increment flu compared to those who didn’t. Recipients had increased demand for requiring medical attending due to the H1N1 virus.
16. Link: Carl Grays article on Time Management http://www.bmj.com/cgi/content/full/316/7137/S2-7137 seemed to become ... (1998). Bmj, 316(7149). doi:10.1136/bmj.316.7149.3a
“In adjusted models, nosotros observed 6.3 (95% CI 1.9–21.5) times to a greater extent than aerosol shedding amid cases amongst vaccination inward the electrical flow too previous flavor compared amongst having no vaccination inward those ii seasons.”
“those who were vaccinated 3 years inward a row genuinely had an increased jeopardy of contracting flu compared amongst unvaccinated participants....”
Prior twelvemonth vaccination cutting the electrical flow twelvemonth efficacy of the flu vaccine.
Children who larn the flu vaccine convey 3 times the charge per unit of measurement of hospitalization for flu.
20.Vaccine-Induced Anti-HA2 Antibodies Promote Virus Fusion too Enhance Influenza Virus Respiratory Disease, Sci Transl Med 28 August 2013: Vol. 5, Issue 200, p. 200ra114 Sci. Transl. Med.
"A novel study inward the U.S. has shown that pigs vaccinated against i strain of flu were worse off if later on infected past times a related strain of the virus."
21.Effectiveness of trivalent inactivated flu vaccine inward influenza-related hospitalization inward children: a case-control study. Joshi AY1, Iyer VN, Hartz MF, Patel AM, Li JT
TIV (The inactivated flu vaccine) did non render whatever protection against hospitalization inward pediatric subjects, peculiarly children amongst asthma. On the contrary, nosotros institute a threefold increased jeopardy of hospitalization inward subjects who did larn the TIV vaccine.
22.Influenza vaccines seem to last modifying flu into a unsafe dengue similar disease.
23.Death rates due to actual positive flu tests average nether 1000 per twelvemonth inward over 300,000,000 patients according to the CDC National Vital Statistics Report. The issue that y'all take heed inward the media of 30K to 50K deaths are due to flu AND pneumonia (all crusade pneumonia including from HIV, COPD, elderly, cancer etc). The issue is inflated to increment flu vaccination. Pediatric flu deaths are reportable too attain from 60-120 annually. Adult flu deaths are non reportable but obtained via expiry certificates too thus that gives liberty for "estimation" to become from a 1000 to the 10's of thousands amongst no existent proof. It is foreign that if at that spot are 30-50K deaths from flu too pneumonia that 80% would last from flu when it alone happens a few months out of the year.
24. Adverse reactions- flawed due to reporter bias. Our grooming is to tell that whatever important flu similar illness is probable coincidence or would convey been worse without the vaccine. We are non trained to recognize serum sickness too nosotros are also besides busy to report.
Miller’s Review of Critical Vaccine Studies used every bit a resource
25.Nanri, A., Nakamoto, K., Sakamoto, N., Imai, T., Akter, S., Nonaka, D., & Mizoue, T. (2017). Association of serum 25-hydroxyvitamin D amongst flu inward case-control study nested inward a cohort of Japanese employees. Clinical Nutrition, 36(5), 1288-1293. doi:10.1016/j.clnu.2016.08.016
Lower flu jeopardy associated amongst vitamin D sufficiency amid unvaccinated participants warrants farther investigation.
Link:
26. Roos R. Study: Prior-year vaccination cutting flu vaccine effects inward 2014-15. CIDRP News. In: Center for Infectious Disease Research too Policy website. Available at http://www.cidrap.umn.edu/news-perspective/2016/04/study-prior-year-vaccination-cut-flu-vaccine-effects-2014-15. Accessed 08Nov16.
27. Smith DJ, Forrest S, Ackley DH, Perelson AS. Variable efficacy of repeated annual flu vaccination. Proc Natl Acad Sci U southward H5N1 1999; 96:14001–6. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24180/pdf/pq014001.pdf.
28. Skowronski, D. M., & Serres, G. D. (2018). Role of Egg-adaptation Mutations inward Low Influenza A(H3N2) Vaccine Effectiveness During the 2012–2013 Season. Clinical Infectious Diseases. doi:10.1093/cid/ciy350
Using a example command study pattern too information from Canada's Sentinel Practitioner Surveillance Network (SPSN) for the 2014-2015 flu season, Dr. Skowronski’s grouping reported that study participants who received the 2014–2015 vaccine without vaccination the twelvemonth earlier had important protection against flu A(H3N2) but those who had received the identical 2013-2014 vaccine the previous twelvemonth had no increased protection too those who were vaccinated 3 years inward a row genuinely had an increased jeopardy of contracting flu compared amongst unvaccinated participants.
29. Systemic autoimmunity appears to last the inevitable upshot of over-stimulating the host’s immune organization past times repeated immunization.
30. The Autoimmune/Inflammatory Syndrome induced past times adjuvants (ASIA)
31.Subgroup analysis demonstrates that immunosuppressive therapies too the nonadjuvanted Pb to less immunogenicity inward humoral answer inward flu-vaccinated SLE patients.
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